YC’s 2026 Roadmap Signals A Shift From Human-Augmented To AI-Native Startups

Y Combinator has released its Spring 2026 Request for Startups, with a clear message: artificial intelligence has moved beyond transforming software. Six of the seven highlighted opportunities center on AI systems that actively replace humans rather than assist them. This may be venture capital’s clearest signal yet that the industry is betting on automation over augmentation.

How Jeffrey Epstein Helped His Publicist Become A Big-Time Venture Capitalist

Masha Bucher is one of the more high profile female VCs in Silicon Valley. New emails released from the Department of Justice reveal a deep, years long relationship with convicted sex trafficker Jeffrey Epstein.

Conditions At ICE Detention Centers Could Fuel Major Measles Outbreaks

In this week’s edition of InnovationRx, we look at we look at Reed Jobs’ cancer-focused VC fund, Midi Health’s latest fundraise at $1 billion-plus valuation, and more.

The Rise Of Co-Investments And How Direct Deal Participation Is Reshaping Private Capital

The private equity landscape is experiencing a fundamental shift in how limited partners (LPs) and general partners (GPs) collaborate on investment opportunities. Co-investments, where LPs invest directly alongside GPs in specific portfolio companies, …

We’re Ranking AI Models All Wrong And Why Human Capability Should Drive The Benchmark

At a moment when the AI industry is obsessed with bigger models and higher scores, Professor Ganna Pogrebna opened the inaugural Behavioral AI Institute webinar with a provocation that cut against the grain. “We keep asking, ‘What can AI do?’” she tol…

AI, Bubbles, The Psychology Of Markets And What Harvard Is Teaching Leaders About Investing In Irrational Times

While everyone is discussing are we in an AI bubble or not, Harvard is teaching how to invest in these irrational times.

Reed Jobs Lost His Father Steve To Cancer. Now His Cancer VC Firm Has Raised $200 Million.

Yosemite, which funds startups and researchers focused on the disease, is targeting a total of $350 million for its second fund from high-powered investors like pharma giant Amgen and hospital Memorial Sloan Kettering.

How Portable Ultrasounds Keep Astronauts Healthy

In this week’s edition of The Prototype, we look at how a new discovery could lead to unsinkable ships, the billions invested in AI “neolabs” and more.

The Health Risks Of Winter Storms

In this week’s edition of InnovationRx, In this week’s edition of InnovationRx, we look at the health risks of winter storms, a new Korean weight loss drug billionaire, a biotech using AI for rare diseases, and more.

VC firm 2150 raises €210M fund to solve cities’ climate challenges

Europe-based venture fund 2150 raised the money to invest in climate tech startups that help solve cities’ carbon footprint.