Embedded in the body’s mucosal surfaces, proteins called lectins bind to sugars found on cell surfaces. A team led by MIT chemistry professor Laura Kiessling has found that one such protein, intelectin-2, both helps fortify the mucosal barrier and offers broad-spectrum protection against harmful bacteria found in the GI tract. Intelectin-2 binds to a sugar…
Launching from the Lab: Building a Deep-Tech StartupBy Lita Nelsen ’64, SM ’66, SM ’79, former director of the MIT Technology Licensing Office, and Maureen StancikBoyce, SM ’91, SM ’93, PhD ’95, with Sophie Hagerty MIT PRESS, 2026, $35 Empty Vessel: The Story of the Global Economy in One BargeBy Ian Kumekawa, lecturer in historyPENGUIN RANDOM…
Antibody treatments for cancer and other diseases are typically delivered intravenously, requiring patients to go to a hospital and potentially spend hours receiving infusions. Now Professor Patrick Doyle and his colleagues have taken a major step toward reformulating antibodies so that they can be injected with a standard syringe, making treatment easier and more accessible. …
Researchers at MIT and Microsoft have used artificial intelligence to create molecular sensors that could detect early signs of cancer via a urine test. The researchers developed an AI model to design short proteins that are targeted by enzymes called proteases, which are overactive in cancer cells. Nanoparticles coated with these proteins, called peptides, can…
As people age, their immune function weakens. Owing to shrinkage of the thymus, where T cells normally mature and diversify, populations of these immune cells become smaller and can’t react to pathogens as quickly. But researchers at MIT and the Broad Institute have now found a way to overcome that decline by temporarily programming cells…
In the vision disorder amblyopia (or “lazy eye”), impaired vision in one eye early in life causes neural connections in the brain’s visual system to shift toward supporting the other eye, leaving the amblyopic eye less capable even if the original impairment is corrected. Current interventions don’t work after infancy and early childhood, when the…
MIT researchers have developed a new method for designing 3D structures that can spring up from a flat sheet of interconnected tiles with a single pull of a string. The technique could be used to make foldable bike helmets and medical devices, emergency shelters and field hospitals for disaster zones, and much more. Mina Konaković…
The Massachusetts Bay Transportation Authority moves hundreds of thousands of people across Greater Boston each day—thanks to a vast system of buses, trains, and ferries that depends on coordination among thousands of employees. In this storied transit system, history runs deep: The Green Line still passes through the country’s oldest subway tunnels, built beneath the…
Several years ago, Suzanne Berger was visiting a manufacturing facility in Ohio, talking to workers on the shop floor, when a machinist offered a thought that could serve as her current credo. “Technology takes a step forward—workers take a step forward too,” the employee said. Berger, to explain, is an MIT political scientist who for…